Neuroblastoma is a cancer of the sympathetic nervous system that commonly affects children of age 5 or younger. We are working to help categorize the disease as favorable or unfavorable based on morphological characteristics in order to help clinicians determine the severity of a patient’s case so an appropriate treatment plan can be designed.
Current Findings: Neuroblastoma histology is categorized into subgroups that have prognostic significance based on the Schwannian stromal development, grade of differentiation, and mitosis-karyorrhexis index (MKI). We have developed systems that can effectively aid in determining the histology of a neuroblastoma image.
Figure 1: Types of neuroblastoma
The diagram above shows the different images of the different subgroups of neuroblastoma. Based on the morphological characteristics of these images, we were able to extract features for analysis and correctly classify the grade of differentiation and stroma development with 88.9% and 88.4% accuracy, respectively. The flow chart below summarizes the classification process.
Figure 2 : Grading of differentiation
Figure 3 : Neuroblastoma Image Analysis Results