Wake Forest Translational Science Institute (TSI)

Clinical Research Unit

Overview

The Clinical Research Unit (CRU) provides infrastructure to support clinical projects by offering access to clinical research space, resources, research support personnel, and expertise.

Detail

Dedicated Clinical Space

  • Main Clinical Research Unit: 9 Exam Rooms, 1 Procedure Room, a Metabolic Kitchen, Dining Room, and a CLIA-Certified Processing Core. Standard Operating Hours: 6:30AM-4:30PM.
  • Geriatric Clinical Research Unit: 5 Exam Rooms, Dining Room, and Processing Laboratory.

Ancillary Support

The CRU may be able to provide support for laboratory or imaging components of CRU-approved pilot studies. Please contact Rachel Woodside at rwoodsid@wakehealth.edu for more information.

Physician Assistant Support

The CRU employs a full-time Physician Assistant to extend the services available to investigators. Available services are open to discussion based on training and competency, but examples include:

  • Histories and Physicals
  • Muscle Biopsies
  • Fat Biopsies
  • Lumbar Punctures

Research Nursing Support

The CRU nursing staff provides research support for pediatric and adult research projects. Available services include:

  • Ankle Brachial Index (ABI)
  • Autonomic Function Assessments
  • Basic Phlebotomy
  • Bronchoscopy- Assist and Set-Up
  • Cardiac Monitoring
  • Clotting Time Procedures
  • Complete Study-Specific Forms
  • Conscious Sedation
  • Eye (chart) and Hearing Exams
  • Frequently Sampled Intravenous Glucose Tolerance Test (FSIGT)
  • Intramuscular and Subcutaneous Injections
  • IV Medication Administration
  • LP- Assist and Set-Up
  • Mental and Cognitive Testing
  • Muscle Biopsy- Assist and Set-Up
  • Oral Glucose Tolerance Testing (OGTT)
  • Pharmacokinetics (PK) Studies
  • Sample Collection (Blood, Sputum, Urine) (Including Saline Lock)
  • Vital Signs (EKG, Blood Pressure, Height, Weight, etc.)

Bionutrition Support

Bionutrition Service provides three main areas of support: food service, nutrition assessments, and nutritional education. Services Include:

  • Aliquot Preparation for Meal Assays
  • Anthropometric Body Measurements
  • Bioelectrical Impedance (BIA) Measurement
  • Collection and Analysis of Dietary Intake Data from Dietary Recalls or Records
  • Computer-Assisted Food Weigh-Back System
  • Computer-Assisted Menu Planning for Research Diets
  • Controlled Nutrient Diet Planning, Analysis, and Preparation
  • Development of Protocol-Specific Educational Materials
  • Dietary Compliance Monitoring and Assessment
  • Doubly-Labeled Water Testing
  • Vitamin, Mineral, and Herbal Supplement Intake Assessment
  • Food Frequency Questionnaire Administration and Analysis
  • Health Snacks for Fasting Visits
  • Indirect Calorimetry (RMR) Testing
  • Metabolic Kitchen Services
  • Nutrition Screening and Evaluation for Feeding Study Eligibility
  • Nutritional Status and Dietary History Assessments
  • On-Site and Pack-Out Research Meal Feeding
  • Recipe Development
  • Registered Dietician Services for Nutrition Counseling
  • Self-Monitoring Tools Development, Implementation, and Analysis

Specimen Processing Support

The CRU Specimen Processing Laboratory provides processing support for blood, saliva, sputum, breast milk, urine, and fecal specimens in the Main and Geriatric Units. The Laboratory is equipped with -70 Freezers, -20 Freezers, Refrigerators, Refrigerated Centrifuges, Micro-Centrifuges, Micropipettes, and Fume Hoods. Available Services include:

  • Buffy Coat Purification
  • Collaboration with LabCorp and Institutional Core Laboratories
  • IV Glucose Tolerance Testing
  • Non-Waived Testing (YSI 2300 STAT Plus Glucose Analyzer)
  • Oral Glucose Tolerance Testing
  • Pharmacokinetic (PK) and Pharmacodynamic (PD) Specimen Processing
  • Preparation and Routing of Specimens for Immediate Analysis
  • Preservation of Specimens for Transport, Ambient, Refrigerated, and Frozen on Dry Ice
  • Processing of Blood, CSF, Specific Cells, Sputum, Saliva, Breast Milk, Urine, Feces, and Tissue
  • Real Time Results Reporting
  • Short-Term Repository Storage
  • Timed Urine Collection
  • Validation of Point of Care Testing Instruments, Including Development of QC and QA Programs

Contact Information

Access

Investigators interested in applying for CRU support can access the application through the Wake Forest eIRB System (internal). To receive assistance or learn more about the application process, please contact Rachel Woodside at rwoodsid@wakehealth.edu.